ABSTRACT
Relatamos a ocorrência da Síndrome Inflamatória da RecuperaçãoImune (IRIS), após reversão de agranulocitose, induzida por poliquimioterapia,em paciente do sexo feminino acometida por hanseníasedimorfa-virchowiana. Propomos que em todos os pacientes submetidosà poliquimioterapia para hanseníase sejam efetuados periodicamenteexames laboratoriais que possam identificar precocementedistúrbios hematológicos graves
We report the occurrence of Immune Reconstitution InflammatorySyndrome (IRIS) after reversal of agranulocytosis provoked by drugor drugs used in the treatment of leprosy. After suspension of thedrugs under suspicion and the recovery of the hematologic disturbanceand as consequence the restoration of the immune conditionwe started an alternate treatment for Hansens disease. Takingthis case as an example, we propose that all patients with leprosyand under treatment with drugs such as dapsone and/ or rifampicinshould have a periodical hemogram to identify premature hematologicanomalies.
Subject(s)
Female , Humans , Adult , Agranulocytosis , Leprosy, Multibacillary , Immune Reconstitution Inflammatory Syndrome , Clofazimine , Dapsone , Drug Therapy, Combination , Case Reports , RifampinABSTRACT
Multidrug therapy (WHO/MDT) in multibacillary leprosy consists of treatment with rifampicin, dapsone andclofazimine. However, adverse effects can cause the patient to abandon treatment. We report on a patient whopresented agranulocytosis and hemolytic anemia associated with this treatment regime. We also examined theimportance of laboratory exams for diagnosis and follow-up of the patient, and for early detection of adverse effects, with a view to improving adhesion to treatment and contributing to the eradication of Hansens disease as a public health issue.
Subject(s)
Adult , Female , Humans , Agranulocytosis/chemically induced , Anemia, Hemolytic/chemically induced , Leprostatic Agents/adverse effects , Clofazimine/adverse effects , Dapsone/adverse effects , Drug Therapy, Combination/adverse effects , Leprosy/drug therapy , Rifampin/adverse effectsABSTRACT
Neste trabalho säo apresentadas as estatísticas do ambulatório de Dermatologia da UFPB durante o período de 1979 a 1983. Foram computados 5.223 casos, incluindo-se dados referentes a idade, sexo e raça. Comentam-se os cinco grupos de moléstias mais freqüentes, com a supremacia dos eczemas com 18,93%